4705. Hexobendine

Nomenclature

CAS number: 54-03-5
3,4,5-Trimethoxybenzoic acid 1,2-ethanediylbis[(methylimino)-3,1-propanediyl] ester; 3,4,5-trimethoxybenzoic acid diester with 3,3′-[ethylenebis(methylimino)]di-1-propanol; N,N′-dimethyl-N,N′-bis[3-(3′,4′,5′-trimethoxybenzoxy)propyl]ethylenediamine; hexabendin.
C30H44N2O10; mol wt 592.68.
C 60.80%, H 7.48%, N 4.73%, O 27.00%.

Description and references

Prepn: O. Kraupp, K. Schlgl, AT 231432; eidem, US 3267103 (1964, 1966 both to OSSW). Pharmacology: Rudolph et al., Arzneim.-Forsch. 20, 637 (1970); Kolassa, Pfleger, Biochem. Pharmacol. 20, 490 (1971); H. Rameis et al., Arzneim.-Forsch. 30, 671 (1980).

Chemical structure

Properties

mp 75-77°.

Derivative

Dihydrochloride.

Nomenclature

CAS number: 50-62-4
ST-7090; Reoxyl (Byk Gulden); Ustimon; Andiamine (Polfa).
C30H44N2O10.2HCl; mol wt 665.60.
C 54.13%, H 6.97%, N 4.21%, O 24.04%, Cl 10.65%.

Properties

Crystals, mp 170-174°. uv max: 267 nm. Freely sol in water, less sol in alc. Practically insol in ether.

Therapeutic Category

Vasodilator (coronary).

Keywords

Vasodilator (Coronary)