4706. Hexocyclium Methyl Sulfate

Nomenclature

CAS number: 115-63-9
4-(2-Cyclohexyl-2-hydroxy-2-phenylethyl)-1,1-dimethylpiperazinium methyl sulfate (salt); N-(β-cyclohexyl-β-hydroxy-β-phenylethyl)-N1-methylpiperazine methosulfate; N-(β-cyclohexyl-β-hydroxy-β-phenylethyl)-N1-methylpiperazine dimethylsulfate; 4-(β-cyclohexyl-β-hydroxy-β-phenethyl)-1,1-dimethylpiperazinium methyl sulfate; Tral (Abbott); Tralin.
C21H36N2O5S; mol wt 428.59.
C 58.85%, H 8.47%, N 6.54%, O 18.67%, S 7.48%.

Description and references

Anticholinergic. Description: Helgren et al., J. Am. Pharm. Assoc. Sci. Ed. 46, 639 (1957). Prepn: Weston, US 2907765 (1959 to Abbott).

Chemical structure

Properties

Crystals, mp 200-210°. uv max (0.1N H2SO4): 252, 257, 263 nm. Soly in water about 50% w/v. Slightly sol in chloroform. Insol in ether.

Therapeutic Category

Antispasmodic.

Keywords

Antimuscarinic