4713. Hexythiazox

Nomenclature

CAS number: 78587-05-0
(4R,5R)-rel-5-(4-Chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxamide; trans-4-methyl-5-(4-chlorophenyl)-3-cyclohexylcarbamoyl-2-thiazolidone; HTZ; NA-73; DPX-Y5893-9; Nissorun (Nippon Soda); Acariflor (Sipcam); Cesar (AgrEvo); Savey (Gowan); Zeldox (Zeneca).
C17H21ClN2O2S; mol wt 352.88.
C 57.86%, H 6.00%, Cl 10.05%, N 7.94%, O 9.07%, S 9.09%.

Description and references

Prepn: I. Iwataki et al., DE 3037105; eidem, US 4442116 (1981, 1984 to Nippon Soda). Miticidal activity: M. A. Hoy, Y.- L. Ouyang, J. Econ. Entomol. 79, 1377 (1986); C. Welty et al., ibid. 81, 586 (1988). Residue determn in crops: M. Tokieda et al., J. Pestic. Sci. 12, 711 (1987), C.A. 108, 162770b (1988). Brief description of physical properties, toxicity and efficacy: Nippon Soda Co., Ltd., Jpn. Pestic. Inf. 44, 21 (1984).

Chemical structure

Properties

White odorless crystals, mp 105.5°. Vapor pressure at 20°: 2.54 × 108 mm Hg. Soly at 20° (g/100 ml): acetone 16, chloroform 137.9, methanol 2.06, n-hexane 0.39, xylene 36.2, acetonitrile 2.86; water 0.5 ppm. LD50 in male, female mice, male, female rats (mg/kg): all >5000 orally; all >5000 dermally (Nippon Soda Co.).

Use

Acaricide.