4786. Hydrocortamate

Nomenclature

CAS number: 76-47-1
N,N-Diethylglycine (11β)-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl ester; cortisol 21-ester with N,N-diethylglycine; cortisol 21-(N,N-diethyl)glycinate; hydrocortisone 21-diethylaminoacetate; Ulcort.
C27H41NO6; mol wt 475.62.
C 68.18%, H 8.69%, N 2.94%, O 20.18%.

Description and references

Prepn: Pinson, Laubach, DE 1016708 (1957 to Pfizer), C.A. 54, 22737a (1960); Richter, Schenck, DE 1037451 (1958 to Schering AG), C.A. 54, 22730h (1960).

Chemical structure

Properties

Crystals from ethyl acetate, mp 162-163°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 125-03-1
Ethamicort; Magnacort (Pfizer).
C27H41NO6.HCl; mol wt 512.08.
C 63.33%, H 8.27%, N 2.74%, O 18.75%, Cl 6.92%.

Properties

Crystals from ethyl acetate, dec 222°.

Therapeutic Category

Glucocorticoid.

Keywords

Glucocorticoid