4833. N-(Hydroxymethyl)nicotinamide

Nomenclature

CAS number: 3569-99-1
N-(Hydroxymethyl)-3-pyridinecarboxamide; 3-pyridinecarboxylic acid hydroxymethylamide; pyridine-3-carboxylic acid N-methylolamide; Bilamid(e) (Cilag-Chemie); Felosan; Nikoform; Choligen.
C7H8N2O2; mol wt 152.15.
C 55.26%, H 5.30%, N 18.41%, O 21.03%.

Description and references

Prepn: Graf, J. Prakt. Chem. 138, 292 (1933); Chechelska, Urbanski, Rocz. Chem. 27, 396 (1953), C.A. 49, 1033f (1955).

Chemical structure

Properties

Crystals, mp 141-142°. Freely sol in hot alcohol and water; sparingly sol in cold alcohol and water.

Derivative

Hydrochloride.
C7H8N2O2.HCl; mol wt 188.61.
C 44.58%, H 4.81%, N 14.85%, O 16.97%, Cl 18.80%.

Properties

Crystals, mp >120° (dec).

Therapeutic Category

Cholagogue.