4846. Hydroxytetracaine

Nomenclature

CAS number: 490-98-2
4-Butylamino-2-hydroxybenzoic acid 2-dimethylaminoethyl ester; p-butylaminosalicylic acid 2-dimethylaminoethyl ester; 2-dimethylaminoethyl p-butylaminosalicylate; hydroxamethocaine; Rhenocain; Salicain (Hoechst).
C15H24N2O3; mol wt 280.36.
C 64.26%, H 8.63%, N 9.99%, O 17.12%.

Description and references

Prepn: GB 736960 (1955); GB 760003 (1956 to Rheinpreussen AG); Grimme, Schmitz, Ber. 84, 734 (1951).

Chemical structure

Derivative

Hydrochloride.
C15H24N2O3.HCl; mol wt 316.82.
C 56.87%, H 7.95%, N 8.84%, O 15.15%, Cl 11.19%.

Properties

Crystals from water, mp 157°. Soly in water at 20°: about 4%.

Derivative

Hemihydrate.

Properties

Prisms from ligroin, mp 48°.

Therapeutic Category

Anesthetic (local).

Keywords

Anesthetic (Local)