4854. Hymecromone

Nomenclature

CAS number: 90-33-5
7-Hydroxy-4-methyl-2H-1-benzopyran-2-one; 7-hydroxy-4-methylcoumarin; 7-hydroxy-4-methyl-2-oxo-3-chromene; 4-methylumbelliferone; β-methylumbelliferone; imecromone; 4-MU; Bilcolic (Unifa); Biliton H (Berlin-Chemie); Cantabilin (Formenti); Cantabiline; Cholonerton (Dolorgiet); Cholspasmin (Lipha); Cumarote C (Towa Yakuhin); Himecol (Kissei); Medilla (Omega); Mendiaxon (Roland).
C10H8O3; mol wt 176.17.
C 68.18%, H 4.58%, O 27.25%.

Description and references

Prepd from resorcinol and ethyl acetoacetate: Pechmann, Duisberg, Ber. 16, 2119 (1883); Russell, Frye, Org. Synth. 21, 23 (1941); Woods, Sapp, J. Org. Chem. 27, 3703 (1962). Use in determn of nitric acid: F. J. Welcher, Organic Analytical Reagents vol. 1 (Van Nostrand, New York, 1947) pp 214-215.

Chemical structure

Properties

Crystals from alc, mp 194-195° (Woods, Sapp), formerly reported as 185-186° (Pechmann, Duisberg). uv max (methanol): 221, 251, 322.5 nm. Blue fluorescence in alcohol + water. Sol in methanol, glacial acetic acid; slightly sol in ether, chloroform. Practically insol in cold water.

Use

Analytical reagent.

Therapeutic Category

Choleretic; antispasmodic.

Keywords

Antispasmodic; Choleretic