4873. Ibandronic Acid

Nomenclature

CAS number: 114084-78-5
[1-Hydroxy-3-(methylpentylamino)propylidene]bisphosphonic acid.
C9H23NO7P2; mol wt 319.23.
C 33.86%, H 7.26%, N 4.39%, O 35.08%, P 19.41%.

Description and references

Bisphosphonate antiresorptive agent. Prepn: R. Gall, E. Bosies, DE 3623397; eidem, US 4927814 (1988, 1990 both to Boehringer Mann.). Inhibition of bone resorption: R. C. Mühlbauer et al., J. Bone Miner. Res. 6, 1003 (1991). Mechanism of action study: C. Vitté et al., Endocrinology 137, 2324 (1996). Clinical trial in cancer-associated hypercalcemia: M. Pecherstorfer et al., J. Clin. Oncol. 14, 268 (1996); in osteoporosis: P. Ravn et al., Bone 19, 527 (1996). Review of pharmacology and clinical efficacy: M. Dooley, J. A. Balfour, Drugs 57, 101-108 (1999); of clinical experience in osteoporosis: R. D. Chapurlat, P. D. Delmas, Expert Opin. Pharmacother. 4, 391-396 (2003); of development and therapeutic potential: L. Gennari, IDrugs 8, 155-169 (2005).

Chemical structure

Properties

Dec 84°.

Derivative

Sodium salt.

Nomenclature

CAS number: 138926-19-9 (monohydrate); 138844-81-2 (anhydrous)
Ibandronate sodium; BM-21.0955; Bondronat (Roche); Boniva (Roche); Bonviva (Roche).
C9H22NNaO7P2; mol wt 341.21.
C 31.68%, H 6.50%, N 4.11%, Na 6.74%, O 32.82%, P 18.16%.

Properties

Occurs as the monohydrate.

Therapeutic Category

Bone resorption inhibitor.

Keywords

Antiosteoporotic; Bone Resorption Inhibitor