4872. Ibafloxacin
Nomenclature
CAS number: 91618-36-9
9-Fluoro-6,7-dihydro-5,8-dimethyl-1-oxo-1H,5H-benzo[ij]quinolizine-2-carboxylic acid; R-835; S-25930. C15H14FNO3; mol wt 275.27.
C 65.45%, H 5.13%, F 6.90%, N 5.09%, O 17.44%.
Description and references
Tricyclic fluorinated quinolone-type antibacterial; related to flumequine, q.v. Prepn: R. M. Stern, EP 109284; idem, US 4472405 (both 1984 to Riker Labs.). Antimicrobial spectrum: L. J. V. Piddock et al., Eur. J. Clin. Microbiol. 5, 303 (1986); K. V. I. Rolston et al., Eur. J. Clin. Microbiol. Infect. Dis. 7, 681 (1988). Synthesis, absolute configuration and antibacterial activity of enantiomers: J. F. Gerster et al., J. Med. Chem. 30, 839 (1987).
