4893. Idrocilamide

Nomenclature

CAS number: 6961-46-2
N-(2-Hydroxyethyl)-3-phenyl-2-propenamide; N-(2-hydroxyethyl)cinnamamide; LCB-29; Brolitène (Lab. Medicia); Srilane (Medicia).
C11H13NO2; mol wt 191.23.
C 69.09%, H 6.85%, N 7.32%, O 16.73%.

Description and references

Prepn: M. Bayssat et al., DE 2015447; eidem, US 3659014 (1970, 1972 to LIPHA); Chim. Ther. 8, 202 (1973). Pharmacology: Grand et al., Eur. J. Med. Chem. 9, 205 (1974). Metabolism: Belleville et al., Therapie 29, 829 (1974).

Chemical structure

Properties

White crystals from ethyl acetate or acetone, mp 100-102°. Soluble in alcohol; slightly sol in water. LD50 orally in mice, rats: >2950, >3000 mg/kg (Grand).

Therapeutic Category

Muscle relaxant (skeletal).

Keywords

Muscle Relaxant (Skeletal)