4915. Imidocarb

Nomenclature

CAS number: 27885-92-3
N,N′-Bis[3-(4,5-dihydro-1H-imidazol-2-yl)phenyl]urea; 3,3′-di-2-imidazolin-2-ylcarbanilide.
C19H20N6O; mol wt 348.40.
C 65.50%, H 5.79%, N 24.12%, O 4.59%.

Description and references

Prepn: GB 1007334; R. Fischer, R. Hirt, US 3338917 (1965, 1967 both to Wander). Babesicidal effect in mice and rats: G. Schmidt et al., Res. Vet. Sci. 10, 530 (1969); E. Beveridge, ibid. 534. Effect on exptl anaplasmosis in calves: T. O. Roby, ibid. 13, 519 (1972). Comparison of the dipropionate and tetracycline, q.v., in canine ehrlichiosis: J. E. Price, T. T. Dolan, Vet. Rec. 107, 275 (1980). Efficacy in Babesia felis infection: F. T. Potgieter, J. S. Afr. Vet. Assoc. 52, 289 (1981). Effect on B. ovis infection in sheep: S. A. Michael, A. H. El Refaii, Trop. Anim. Health Prod. 14, 1 (1982), C.A. 96, 192991 (1982).

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 5318-76-3
Imizocarb; 4A65.
C19H20N6O.2HCl; mol wt 421.32.
C 54.16%, H 5.26%, N 19.95%, O 3.80%, Cl 16.83%.

Properties

Solid, mp 350° (dec). LD50 in mice, rats (mg/kg): 107, 150 s.c. (Beveridge).

Derivative

Dipropionate.

Nomenclature

Imizol; Imizad Equine Injection (Burroughs Wellcome).
C25H32N6O7; mol wt 528.56.
C 56.81%, H 6.10%, N 15.90%, O 21.19%.

Therapeutic Category (Veterinary)

Antiprotozoal (Babesia).