5008. Iobitridol

Nomenclature

CAS number: 136949-58-1
N,N′-Bis(2,3-dihydroxypropyl)-5-[[3-hydroxy-2-(hydroxymethyl)-1-oxopropyl]amino]-2,4,6-triiodo-N,N′-dimethyl-1,3-benzenedicarboxamide; 5-[3-hydroxy-2-(hydroxymethyl)-propionamido]-N,N′-dimethyl-N,N′-bis-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide; Xenetix (Guerbet).
C20H28I3N3O9; mol wt 835.16.
C 28.76%, H 3.38%, I 45.59%, N 5.03%, O 17.24%.

Description and references

Nonionic, monomeric, low-osmolality x-ray contrast medium for urography and angiography. Prepn: M. Schaefer et al., EP 437144; eidem, US 5043152 (both 1991 to Guerbet). Biodistribution studies: P. Bourrinet et al., Invest. Radiol. 29, 1057 (1994). HPLC determn in biological fluids: idem et al., J. Chromatogr. B 670, 369 (1995). Toxicology: A.-M. Donadieu et al., Acta Radiol. 37, Suppl. 400, 17 (1996). Series of articles on pharmacology, pharmacokinetics and clinical studies: ibid. 1-92.

Chemical structure

Properties

Hydrophilic. Log P (octanol/water): 2.63 at 37°. LD50 in male, female mice (g I/kg): 16.8, 16.6 i.v. (Donadieu).

Therapeutic Category

Diagnostic aid (radiopaque medium).

Keywords

Diagnostic Aid (Radiopaque Medium)