5009. Iocarmic Acid

Nomenclature

CAS number: 10397-75-8
3,3′-[(1,6-Dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo-5-[(methylamino)carbonyl]benzoic acid]; 5,5′-(adipoyldiimino)bis[2,4,6-triiodo-N-methylisophthalamic acid]; Myelotrast (Winthrop).
C24H20I6N4O8; mol wt 1253.86.
C 22.99%, H 1.61%, I 60.73%, N 4.47%, O 10.21%.

Description and references

Prepn: GB 1033695; US 3290366 (both 1966 to Mallinckrodt); G. B. Hoey et al., J. Med. Chem. 9, 964 (1966). Clinical studies: Kunze, Schiefer, Dtsch. Med. Wochenschr. 97, 245 (1972). Diagnostic use in myelography: P. Ahlgren, Acta Radiol. Diagn. 13, 753 (1972); in hysterosalpingography: H. E. Schutte, Diagn. Imaging 51, 277 (1982). Spinal toxicity in rats: I. O. Skalpe, A. Torvik, Invest. Radiol. 10, 154 (1975).

Chemical structure

Properties

Crystals from dimethylformamide, mp 302° (dec).

Derivative

Di-N-methylglucamine salt.

Nomenclature

CAS number: 54605-45-7
Dimeglumine iocarmate; LM-280; Dimeray (Mallinckrodt); Dimer-X (Byk Gulden); Dirax (Daiichi).
C38H54I6N6O18; mol wt 1644.29.
C 27.76%, H 3.31%, I 46.31%, N 5.11%, O 17.51%.

Properties

Soly in water (25°): 65 g/100 ml.

Therapeutic Category

Diagnostic aid (radiopaque medium).

Keywords

Diagnostic Aid (Radiopaque Medium)