5034. o-Iodohippurate Sodium

Nomenclature

CAS number: 133-17-5
N-(2-Iodobenzoyl)glycine monosodium salt; sodium o-iodohippurate; Hippodin; Jodairol.
C9H7INNaO3; mol wt 327.05.
C 33.05%, H 2.16%, I 38.80%, N 4.28%, Na 7.03%, O 14.68%.

Description and references

“Contains not less than 38.5% nor more than 39% iodine, when calcd to the dried substance.” Prepd by the condensation of o-iodobenzoic acid with glycine, and treatment with NaOH soln: A. P. Sachs, US 2135474 (1938 to Zonite Prods.). Diagnostic use in post-transplant renography: H. Huland, K. Bischoff, J. Urol. 129, 925 (1983); J.-I. D. Jorgensen, J. Ladefoged, Dan. Med. Bull. 34, 50 (1987).

Chemical structure

Derivative

Dihydrate.

Properties

Crystals. Freely sol in water; sol in alcohol and in dil solns of alkalies. An aq soln is neutral or faintly alkaline to litmus.

Derivative

131I-Labeled form.

Nomenclature

CAS number: 881-17-4
Hippuran I 131 (Mallinckrodt); Hipputope (BMS).

Derivative

123I-Labeled form.

Nomenclature

CAS number: 56254-07-0
Nephroflow (Medi-Physics).

Therapeutic Category

Diagnostic aid (radiopaque medium); labeled form as diagnostic aid (radioactive imaging agent).

Keywords

Diagnostic Aid (Radiopaque Medium)

o-Iodohippurate Sodium 123I: Diagnostic Aid (Radioactive Imaging Agent)

o-Iodohippurate Sodium 131I: Diagnostic Aid (Radioactive Imaging Agent)