Nomenclature
CAS number: 75-47-8
Triiodomethane.
CHI
3; mol wt 393.73.
C 3.05%, H 0.26%, I 96.69%.
Description and references
Prepn from acetone, sodium hypochlorite, potassium
iodide, and sodium hydroxide: Glass, Q. J.
Pharm. Pharmacol. 8, 351 (1935); from chloroform
+ methyl iodide: Soroos, Hinkamp, J. Am.
Chem. Soc. 67, 1642 (1945); by electrolysis:
Glasstone, Ind. Chem. 7, 315 (1931). Description of the iodoform reaction: Seelye, Turney, J. Chem. Educ. 36, 572 (1959).
Toxicity study: Kutob, Plaa, Toxicol. Appl.
Pharmacol. 4, 354 (1962).
Properties
Yellow powder or crystals; mp ≈120°; dec at high temp with evolution of
iodine. Unctuous touch; characteristic, disagreeable odor. Volatile
with steam. d 4.1.
Very slightly sol in water. One gram dissolves in 60 ml cold alcohol,
16 ml boiling alcohol, 10 ml chloroform, 7.5 ml ether, 80 ml glycerol,
3 ml carbon disulfide, 34 ml olive oil; freely sol in benzene, acetone,
slightly sol in petr ether. LD50 s.c. in mice: 1.6 mmoles/kg (Kutob, Plaa).Caution
Potential symptoms of overexposure
are irritation of eyes and skin; lightheadedness, dizziness, nausea,
incoordination, CNS depression; dyspnea; liver, kidney and heart damage;
visual disturbances. See NIOSH
Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997)
p 172.Therapeutic Category
Anti-infective (topical).
Therapeutic Category (Veterinary)
Antiseptic, disinfectant for superficial
lesions and in the female reproductive tract.
Keywords
Antiseptic/Disinfectant; Halogens/Halogen Containing Compounds