5063. Iopronic Acid
Nomenclature
CAS number: 41473-08-9
2-[[2-[3-(Acetylamino)-2,4,6-triiodophenoxy]ethoxy]methyl]butanoic
acid; (±)-2-[[2-(3-acetamido-2,4,6-triiodophenoxy)ethoxy]methyl]butyric
acid; 3-[2-(3-acetylamino-2,4,6-triiodophenoxy)ethoxy]-2-ethylpropionic
acid; B-11420; SQ-21983; Bilimiro (Bracco); Bilimiron (Bracco); Oravue (BMS); Videobil (Bracco). C15H18I3NO5; mol wt 673.02.
C 26.77%, H 2.70%, I 56.57%, N 2.08%, O 11.89%.
Description and references
Oral cholecystographic agent. Prepn: E. Felder, D. Pitre, DE 2128902; eidem, US 3842124 (1972, 1974 both to Bracco); E. Felder et al., Farmaco Ed. Sci. 31, 349 (1976). Pharmacology, toxicology: P. Tirone, G. Rosati, Farmaco Ed. Prat. 31, 397, 437 (1976). Series of articles on metabolism: ibid. 516-546; 755. Intestinal absorption: J. R. Amberg et al., Invest. Radiol. 15, S136 (1980). Effect on bile flow and composition: J. L. Barnhart et al., ibid. S124. Toxicity: P. Tirone, G. Rosati, Farmaco Ed. Prat. 31, 397 (1976).
Properties
Crystals from 50% ethanol, mp 130°. LD50 in mice, rats, dogs (mg/kg): 1950, 5650, >3000 orally; 1090, 1000, 835 i.v. (Tirone).Therapeutic Category
Diagnostic aid (radiopaque medium—cholecystographic).
Keywords
Diagnostic Aid (Radiopaque Medium)