5064. Iothalamic Acid

Nomenclature

CAS number: 2276-90-6
3-(Acetylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]benzoic acid; 5-acetamido-2,4,6-triiodo-N-methylisophthalamic acid.
C11H9I3N2O4; mol wt 613.91.
C 21.52%, H 1.48%, I 62.01%, N 4.56%, O 10.42%.

Description and references

Synthesis: Hoey et al., J. Med. Chem. 6, 24 (1963).

Chemical structure

Properties

Crystals, dec about 285°.

Derivative

N-Methylglucamine salt.

Nomenclature

CAS number: 13087-53-1
Meglumine iothalamate; Conray (Mallinckrodt); Contrix “28”; Cysto-Conray (Mallinckrodt).
C18H26I3N3O9; mol wt 809.13.
C 26.72%, H 3.24%, I 47.05%, N 5.19%, O 17.80%.

Derivative

Sodium salt.

Nomenclature

CAS number: 1225-20-3
Sodium iothalamate; Angio-Conray (Mallinckrodt); Angio-Contrix “48”; Conray-400 (Mallinckrodt); Medio-Contrix “38”.
C11H8I3N2NaO4; mol wt 635.90.
C 20.78%, H 1.27%, I 59.87%, N 4.41%, Na 3.62%, O 10.06%.

Derivative

131I-Labeled sodium salt.

Nomenclature

CAS number: 15845-98-4
Glofil-131 (Abbott).

Therapeutic Category

Diagnostic aid (radiopaque medium).

Keywords

Diagnostic Aid (Radiopaque Medium)