5065. Iotrolan

Nomenclature

CAS number: 79770-24-4
5,5′-[(1,3-Dioxo-1,3-propanediyl)bis(methylimino)]bis[N,N′-bis[2,3-dihydroxy-1-(hydroxymethyl)propyl]-2,4,6-triiodo-1,3-benzenedicarboxamide]; 5,5′-[malonylbis(methylimino)]bis[N,N′-bis[2,3-dihydroxy-1-(hydroxymethyl)propyl]-2,4,6-triiodoisophthalamide]; iotrol; DL-3117; SH-437; ZK-39482; Isovist (Schering AG).
C37H48I6N6O18; mol wt 1626.23.
C 27.33%, H 2.98%, I 46.82%, N 5.17%, O 17.71%.

Description and references

Nonionic, isotonic contrast medium. Prepn: M. Sovak, R. Ranganathan, EP 33426; eidem, US 4341756 (1981, 1982 both to Univ. Cal., Berkeley). Neurotoxicity study: M. Sovak et al., Radiology 142, 115 (1982). Neuropharmacology: M. Sovak et al., Am. J. Neuroradiol. 4, 319 (1983); and cerebral distribution: J.-C. Castel et al., Neuroradiology 29, 206 (1987). Arthrographic evaluation in animals: J. Guerra et al., Invest. Radiol. 19, 228 (1983). Cardiovascular effects in animals: P. Lanzer et al., ibid. 20, 746 (1985). Clinical study of patient tolerance and diagnostic adequacy for intrathecal use: B. Hammer, E. Deisenhammer, Neuroradiology 27, 337 (1985); B. Hoffmann et al., ibid. 29, 380 (1987); M. D. Malnor et al., Radiology 158, 845 (1986).

Chemical structure

Properties

Colorless glassy solid. Soly at 20° (mgI/ml): water >400. LD50 in mice, rats (gI/kg): >26, 12.7 i.v. (Sovak, 1982).

Therapeutic Category

Diagnostic aid (radiopaque medium).

Keywords

Diagnostic Aid (Radiopaque Medium)