Composed of a polynuclear ferric hydroxide inner sphere surrounded by sucrose molecules; mol wt 34 to 60 kDa. Prepn: C. Mannich, C. A. Rojahn, Ber. Dtsch. Pharm. Ges. 32, 158 (1922); and use in i.v. treatment of anemia: H. G. B. Slack, J. F. Wilkinson, Lancet 256, 11, 163 (1949). Histological properties: P. Geisser et al., Arzneim.-Forsch. 42, 1439 (1992). Pharmacokinetics: B. G. Danielson et al., ibid. 46, 615 (1996). Clinical evaluation in dialysis-associated anemia: C. Charytan et al., Am. J. Kidney Dis. 37, 300 (2001). Review of clinical experience: J. Yee, A. Besarab, ibid. 40, 1111-1121 (2002).
Hematinic.
Hematinic