5175. Isoflurane

Nomenclature

CAS number: 26675-46-7
2-Chloro-2-(difluoromethoxy)-1,1,1-trifluoroethane; 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether; compd 469; Aerrane (Baxter); Forane (Ohmeda); Forene (Abbott).
C3H2ClF5O; mol wt 184.49.
C 19.53%, H 1.09%, Cl 19.22%, F 51.49%, O 8.67%.

Description and references

Prepn: Croix, Terrell, DE 1814962 (1969); Terrell, US 3535388; US 3535425 (both 1970 to Air Reduction); Terrell et al., J. Med. Chem. 14, 517 (1971). Series of articles on pharmacology: Anesthesiology 35, 8-53 (1971); Byles et al., Can. Anaesth. Soc. J. 18, 376-407 (1971). Enantiomeric resolution: J. Meinwald et al., Science 251, 560 (1991).

Chemical structure

Properties

Clear, colorless liquid having a slight odor. bp 48.5°. Vapor pressure at 25°: 330 mm. sp gr 1.45. nD20 1.3002. Nonflammable; soda lime stable. Easily miscible with organic liquids including fats and oils.

Use

Solvent and dispersant for fluorinated materials.

Therapeutic Category

Anesthetic (inhalation).

Therapeutic Category (Veterinary)

Anesthetic (inhalation).

Keywords

Anesthetic (Inhalation)