5209. Isopropylamine

Nomenclature

CAS number: 75-31-0
2-Propanamine; 2-aminopropane; 1-methylethylamine.
C3H9N; mol wt 59.11.
C 60.96%, H 15.35%, N 23.70%.

Description and references

Prepn from acetone + NH3: Skita, Keil, Ber. 61, 1682 (1928); Norton et al., J. Org. Chem. 19, 1054 (1954) DOI; from acetone oxime: C. F. Winans, H. Adkins, J. Am. Chem. Soc. 55, 2051 (1933) DOI. Toxicity study: H. F. Smyth et al., Arch. Ind. Hyg. Occup. Med. 4, 119 (1951).

Chemical structure

Properties

Colorless, flammable liquid; ammonia odor; strong base. d415 0.694. mp 101°. bp 33-34°. nD15 1.3770. Flash pt, open cup: 15°F (26°C). Miscible with water, alcohol, ether. LD50 orally in rats: 820 mg/kg (Smyth).

Caution

Potential symptoms of overexposure are irritation of eyes, nose, throat and skin; pulmonary edema; visual disturbance; skin and eye burns; dermatitis. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 180.