5224. Isosorbide

Nomenclature

CAS number: 652-67-5
1,4:3,6-Dianhydro-d-glucitol; 1,4:3,6-dianhydrosorbitol; AT-101; NSC-40725; Hydronol (Stuart); Ismotic (Alcon); Isobide (Nikken).
C6H10O4; mol wt 146.14.
C 49.31%, H 6.90%, O 43.79%.

Description and references

Prepd by acid dehydration of d-glucitol: Haworth, Wiggins, GB 600870 (1948). Purification: Hartmann, US 3160641 (1964 to Atlas Chemical Industries). Review of prepn, structure, properties: Wiggins, Adv. Carbohydr. Chem. 5, 191-228 (1950). Stereochemistry: Cope, Shen, J. Am. Chem. Soc. 78, 3177 (1956). Conformation studies: Hopton, Thomas, Can. J. Chem. 47, 2395 (1969). Pharmacodynamics in man: Nodine et al., Clin. Pharmacol. Ther. 14, 196 (1973).

Chemical structure

Properties

Crystals, mp 61-64°. [α]D +44°.

Therapeutic Category

Diuretic.

Keywords

Diuretic