5225. Isosorbide Dinitrate

Nomenclature

CAS number: 87-33-2
1,4:3,6-Dianhydro-d-glucitol dinitrate; dinitrosorbide; 1,4:3,6-dianhydrosorbitol 2,5-dinitrate; Carvasin (Teofarma); Cedocard (Pharmacia); Corovliss (Roche); Dignonitrat (Sankyo); Dilatrate (Schwarz); Diniket (Schwarz); Frandol (Toa Eiyo); Imtack (AstraZeneca); Isocard (Schwarz); Isoket (Schwarz); IsoMack (Mack, Illert.); Isorbid (Wyeth); Isordil (Wyeth); Isostenase (Azupharma); Isotrate (Warner-Chilcott); Langoran (Aventis); Maycor (Parke-Davis); Myorexon (AstraZeneca); Nitorol (Eisai); Nitrol (Altana); Nitrosorbon (Pohl); Rifloc (Avensa); Risordan (Aventis); Sorbangil (Pharmacia); Sorbichew (AstraZeneca); Sorbidilat (AstraZeneca); Sorbid SA (AstraZeneca); Sorbitrate (AstraZeneca); Vascardin (Roche); Vasorbate (Roche).
C6H8N2O8; mol wt 236.14.
C 30.52%, H 3.41%, N 11.86%, O 54.20%.

Description and references

Coronary vasodilator. Prepn from sorbitol: Goldberg, Acta Physiol. Scand. 15, 173 (1948), C.A. 42, 5564 (1948); Kochergin, Titkova, C.A. 54, 8647h (1960). Absorption and disposition in man: H. Laufen et al., Arzneim.-Forsch. 33, 980 (1983). Comprehensive description: L. A. Silvieri, N. J. DeAngelis, Anal. Profiles Drug Subs. 4, 225-244 (1975).

Chemical structure

Properties

Hard colorless crystals, mp 70°. [α]D20 +135° (alc). Sparingly sol in water (1.089 mg/ml, also given as 1.0 g dissolves in 900 ml H2O). Freely sol in organic solvents, such as acetone, alc, ether.

Derivative

Isosorbide-5-mononitrate.

Nomenclature

CAS number: 16051-77-7
Corangin (Novartis); Elan (Schwarz); Elantan (Schwarz); Imdur (Key); Ismo (Roche); Isomonat (Roche); Monicor (Fabre); Monit (Lorex); Mono-Cedocard (Altana); Monoclair (Hennig); Monoket (Schwarz); Mono Mack (Mack, Illert.); Monosorb (Dexcel); Olicard (Solvay); Pentacard (Cedona).
C6H9NO6; mol wt 191.14.
C 37.70%, H 4.75%, N 7.33%, O 50.22%.

Description and references

Metabolite of isosorbide dinitrate.

Therapeutic Category

Antianginal.

Keywords

Antianginal