5227. Isothipendyl

Nomenclature

CAS number: 482-15-5
N,N,α-Trimethyl-10H-pyrido[3,2-b][1,4]benzothiazine-10-ethanamine; 10-(2-dimethylamino-2-methylethyl)-10H-pyrido[3,2-b][1,4]benzothiazine; 10-(2-dimethylaminopropyl)-1-azaphenothiazine; N-dimethylaminoisopropylthiophenylpyridylamine; D-201.
C16H19N3S; mol wt 285.41.
C 67.33%, H 6.71%, N 14.72%, S 11.23%.

Description and references

Prepn: H. L. Yale, F. Sowinski, J. Am. Chem. Soc. 80, 1651 (1958). Pharmacology: A. von Schlichtegroll, Arzneim.-Forsch. 8, 489 (1958). Clinical evaluation: N. W. Klehr et al., Therapiewoche 34, 6050 (1984); E. Milsmann, P. Rohdewald, Dermatologica 170, 230 (1985). Spectroscopic determn: M. H. Abdel-Hay et al., J. Pharm. Belg. 45, 259 (1990). HPLC determn: A. Turcant et al., Clin. Chem. 37, 1210 (1991).

Chemical structure

Properties

bp0.4mm 171-174°. LD50 in mice (mg/kg): 65 ±2 i.p.; 222 ±18 orally (Schlichtegroll).

Derivative

Hydrochloride.

Nomenclature

CAS number: 1225-60-1
Andantol (Sumitomo); Andanton (Lacer); Nilergex.
C16H19N3S.HCl; mol wt 321.87.
C 59.70%, H 6.26%, N 13.05%, S 9.96%, Cl 11.01%.

Properties

Sol in water.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic; Tricyclics; Other Tricyclics