5278. Kallidin

Nomenclature

CAS number: 342-10-9
N2-l-Lysylbradykinin; kallidin-10; kallidin II.
C56H85N17O12; mol wt 1188.38.
C 56.60%, H 7.21%, N 20.04%, O 16.16%.

Description and references

A hypotensive and smooth muscle-stimulating principle formed by the proteolysis of kininogen by glandular and other kallikreins, q.v. The decapeptide structure is a homologue of bradykinin, q.v.: Werle et al., Z. Physiol. Chem. 326, 174 (1961). Synthesis: Nicolaides et al., Biochem. Biophys. Res. Commun. 6, 210 (1961); Pless et al., Helv. Chim. Acta 45, 394 (1962).

Chemical structure

Properties

Amorphous precipitate. [α]D21 57° (c = 1 in N acetic acid). Rf value in a butanol/acetic acid/water system (70:10:20) 0.15.

Therapeutic Category

Vasodilator.

Keywords

Vasodilator (Peripheral)