5288. Kebuzone

Nomenclature

CAS number: 853-34-9
4-(3-Oxobutyl)-1,2-diphenyl-3,5-pyrazolidinedione; 1,2-diphenyl-4-(γ-ketobutyl)-3,5-pyrazolidinedione; 1,2-diphenyl-4-(3′-oxobutyl)-3,5-dioxopyrazolidine; ketophenylbutazone; KPB; Ketazon (Leciva).
C19H18N2O3; mol wt 322.36.
C 70.79%, H 5.63%, N 8.69%, O 14.89%.

Description and references

Nonsteroidal anti-inflammatory agent related to phenylbutazone, q.v. Prepn: Deuss et al., US 2910481 (1959 to Geigy). Review of pharmacology: Horakova et al., Pharmacotherapeutica 1950-1959, 335-350 (1963), C.A. 60, 6072g (1964). Metabolism: Nemecek et al., Arzneim.-Forsch. 16, 1339 (1966); Queisnerova, Nemecek, Cesk. Farm. 20, 55 (1971), C.A. 75, 47077u (1971).

Chemical structure

Properties

Crystals, mp 115.5-116.5° or 127.5-128.5° depending on cryst form.

Therapeutic Category

Anti-inflammatory.

Keywords

Anti-inflammatory (Nonsteroidal); Pyrazolones