5446. Lercanidipine

Nomenclature

CAS number: 100427-26-7
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester; methyl 1,1,N-trimethyl-N-(3,3-diphenylpropyl)-2-aminoethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate; methyl 1,1-dimethyl-2-[N-(3,3-diphenylpropyl)-N-methylamino]ethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; masnidipine.
C36H41N3O6; mol wt 611.73.
C 70.68%, H 6.76%, N 6.87%, O 15.69%.

Description and references

Dihydropyridine calcium channel blocker. Prepn: D. Nardi et al., EP 153016; eidem, US 4705797 (1985, 1987 both to Recordati). Pharmacology: G. Bianchi et al., Pharmacol. Res. 21, 193 (1989). Clinical evaluation in hypertension: E. Rimoldi et al., Acta Ther. 20, 23 (1994).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 132866-11-6
Rec-15-2375; R-75; Lerdip (Recordati); Zanidip (Napp).
C36H41N3O6.HCl; mol wt 648.19.
C 66.71%, H 6.53%, N 6.48%, O 14.81%, Cl 5.47%.

Properties

Prepd as the hemihydrate, mp 119-123°. LD50 in mice (mg/kg): 83 i.p.; 657 orally (Nardi).

Therapeutic Category

Antihypertensive.

Keywords

Antihypertensive; Dihydropyridine Derivatives; Calcium Channel Blocker; Dihydropyridine Derivatives