5447. Lesopitron

Nomenclature

CAS number: 132449-46-8
2-[4-[4-(4-Chloro-1H-pyrazol-1-yl)butyl]-1-piperazinyl]pyrimidine.
C15H21ClN6; mol wt 320.82.
C 56.16%, H 6.60%, Cl 11.05%, N 26.20%.

Description and references

Selective serotonin 5HT1A-receptor agonist. Prepn: A. Colombo Pinol et al., EP 382637; eidem, US 5128343 (1990, 1992 both to Esteve). Receptor binding studies and pharmacology: B. Costall et al., J. Pharmacol. Exp. Ther. 262, 90 (1992); M. Ballarin et al., Br. J. Pharmacol. 113, 425 (1994). Gastroprotective effects: A. J. Farré et al., J. Pharmacol. Exp. Ther. 272, 832 (1995).

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 132449-89-9
E-4424.
C15H21ClN6.2HCl; mol wt 393.74.
C 45.76%, H 5.89%, Cl 27.01%, N 21.34%.

Properties

Crystals, mp 194-197.5°.

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic; Arylpiperazines; Serotonin Receptor Agonist