5449. Letosteine

Nomenclature

CAS number: 53943-88-7
2-[2-[(2-Ethoxy-2-oxoethyl)thio]ethyl]-4-thiazolidinecarboxylic acid; 2-[2-[(carboxymethyl)thio]ethyl]-4-thiazolidinecarboxylic acid 2-ethyl ester; Viscotiol (Erba).
C10H17NO4S2; mol wt 279.38.
C 42.99%, H 6.13%, N 5.01%, O 22.91%, S 22.95%.

Description and references

Cyclic cysteine derivative. Prepn: M. X. Chodkiewicz, DE 2410307; eidem, US 4032534 (1974, 1979 to Ferlux-Chemie). Effect on viscoelasticity of mucus: E. Puchelle et al., Eur. J. Respir. Dis. 61 (Suppl 110), 195 (1980). In treatment of bronchitis: V. Macquet et al., Lille Med. 24, 735 (1979); P. Freour, J. Vergeret, Bordeaux Med. 12, 1553 (1979); P. Freour, ibid. 13, 1431 (1980); P. Meroni et al., Clin. Ter. 105, 109 (1983). Comparison with sulfur-containing compounds in bronchitis: D. Rodde, C. R. Ther. Pharmacol. Clin. 1(5), 31 (1983).

Chemical structure

Properties

Crystals from ethanol, mp 142°.

Therapeutic Category

Mucolytic.

Keywords

Mucolytic