5448. Leteprinim

Nomenclature

CAS number: 138117-50-7
4-[[3-(1,6-Dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]benzoic acid.
C15H13N5O4; mol wt 327.29.
C 55.05%, H 4.00%, N 21.40%, O 19.55%.

Description and references

Synthetic purine derivative with neuroprotective effects. Prepn: A. J. Glasky, WO 9114434 (1991); idem, US 5091432 (1992). Effect on working memory in mice: idem et al., Pharmacol. Biochem. Behav. 47, 325 (1994). Mode of action study: P. J. Middlemiss et al., Neurosci. Lett. 199, 131 (1995). Mechanism of brain efflux: R. Yan, E. M. Taylor, Drug Metab. Dispos. 30, 513 (2002). Reviews of pharmacology: M. P. Rathbone et al., Drug Dev. Res. 45, 356-372 (1998); idem et al., Expert Opin. Invest. Drugs 8, 1255-1262 (1999).

Chemical structure

Properties

White solid, mp 319-321°.

Derivative

Potassium salt.

Nomenclature

CAS number: 192564-13-9
AIT-082; Neotrofin (Spectrum).
C15H13KN5O4; mol wt 366.39.
C 49.17%, H 3.58%, K 10.67%, N 19.11%, O 17.47%.

Therapeutic Category

Nootropic.

Keywords

Nootropic