5585. Lotrifen
Nomenclature
CAS number: 66535-86-2
2-(4-Chlorophenyl)-(1,2,4)triazolo[5,1-a]isoquinoline; 2-(p-chlorophenyl)-s-triazolo[5,1-a]isoquinoline; L-12717; DL-717-IT; Canocenta (Byk Gulden); Privaprol (Lepetit). C16H10ClN3; mol wt 279.72.
C 68.70%, H 3.60%, Cl 12.67%, N 15.02%.
Description and references
Non-hormonal antifertility agent. Prepn: BE 815498; A. Omodei-Salé et al., US 4075341 (1974, 1978 both to Lepetit). Pharmacokinetics: G. GalliΖani et al., J. Pharmacobio-Dyn. 5, 55 (1981). Pregnancy-terminating effect in dogs: G. Galliani, A. Omodei-Salé, J. Small Anim. Pract. 23, 295 (1982). Effect on subsequent fertility: G. Galliani et al., IRCS Med. Sci. 12, 433, 435 (1984). Review: A. Assandri et al., Rev. Drug Metab. Drug Interact. 4, 237 (1982).
