5629. Lynestrenol

Nomenclature

CAS number: 52-76-6
(17α)-19-Norpregn-4-en-20-yn-17-ol; 17α-ethinyl-17β-hydroxyestr-4-ene; 17α-ethynylestr-4-en-17β-ol; 3-desoxynorlutin; ethinylestrenol; Exluton(a) (Organon); Exlutena (Organon); Orgametril (Organon); Orgametil.
C20H28O; mol wt 284.44.
C 84.45%, H 9.92%, O 5.62%.

Description and references

Prepn: de Winter et al., Chem. Ind. (London) 1959, 905. Metabolism: Kamyab et al., Biochem. J. 103, 14P (1967); J. Endocrinol. 42, 337 (1968). Pharmacokinetics and metabolism: H. Kuhl et al., Contraception 26, 303 (1982). Clinical trial of use in normophasic oral contraceptives: N. Dombrowicz et al., ibid. 22, 537 (1980). Review of carcinogenicity studies: IARC Monographs 21, 407-415 (1979).

Chemical structure

Properties

Solid, mp 158-160°. [α]D -13° (chloroform).

Derivative

Mixture with ethinyl estradiol.

Nomenclature

CAS number: 8064-76-4
Fysionorm (Nourypharma); Minilyn (Organon); Ovanon (Nourypharma); Ovoresta (Organon); Yermonil (Novartis).

Derivative

Mixture with mestranol.

Nomenclature

CAS number: 8015-14-3
Lyndiol (Organon).

Therapeutic Category

Progestogen. In combination with estrogen as oral contraceptive.

Keywords

Contraceptive (Oral); Progestogen