5630. Lypressin

Nomenclature

CAS number: 50-57-7
8-l-Lysinevasopressin; Schweine-Vasopressin; Phe3-Lys8-oxytocin; Diapid (Sandoz); Postacton; Syntopressin (Sandoz).
C46H65N13O12S2; mol wt 1056.22.
C 52.31%, H 6.20%, N 17.24%, O 18.18%, S 6.07%.

Description and references

Purification after isolation from hog pituitary glands: Ward, du Vigneaud, J. Biol. Chem. 222, 951 (1956). Structure: du Vigneaud et al., J. Am. Chem. Soc. 75, 4880 (1953); Bartlett et al., ibid. 78, 2905 (1956). Synthesis: du Vigneaud et al., loc. cit.; Bartlett et al., loc. cit.; Bodanszky et al., ibid. 82, 3195 (1960); Boissonnas, Huguenin, Helv. Chim. Acta 43, 182 (1960); Zaoral, Collect. Czech. Chem. Commun. 30, 1853 (1965); Meienhofer, Sano, J. Am. Chem. Soc. 90, 2996 (1968); Meienhofer, Trzeciak, Proc. Natl. Acad. Sci. USA 68, 1006 (1971). Configuration: Schally, Barret, J. Am. Chem. Soc. 87, 2497 (1965). Review: E. Schr"oder, K. Lübke, The Peptides vol. II (Academic Press, New York, 1966) pp 336-350.

Chemical structure

Therapeutic Category

Antidiuretic; vasopressor.

Keywords

Antidiuretic