5769. Mebeverine
Nomenclature
CAS number: 3625-06-7
3,4-Dimethoxybenzoic acid 4-[ethyl[2-(4-methoxyphenyl)-1-methylethyl]amino]butyl
ester; veratric acid 4-[ethyl(p-methoxy-α-methylphenethyl)amino]butyl
ester; 3,4-dimethoxybenzoic acid 4-[ethyl(p-methoxy-α-methylphenethyl)amino]butyl
ester; 4-[ethyl(p-methoxy-α-methylphenethyl)amino]butyl
3,4-dimethoxybenzoate; 4-[N-[2-(p-methoxyphenyl)-1-methylethyl]-N-ethylamino]butyl 3,4-dimethoxybenzoate. C25H35NO5; mol wt 429.55.
C 69.90%, H 8.21%, N 3.26%, O 18.62%.
Description and references
Smooth muscle relaxant. Prepn: BE 609490 C.A. 59, 517b (1963) and T. Kralt et al., DE 1126889; eidem, US 3265577 (1962, 1962, 1966 to N. V. Philips). Pharmacology: G. Bertaccini et al., Farmaco Ed. Sci. 30, 823 (1975).
Derivative
Hydrochloride.Nomenclature
CAS number: 2753-45-9
Colofac (Duphar); Duspatalin (Duphar); Duspatal (Duphar). C25H35NO5.HCl; mol wt 466.01.
C 64.43%, H 7.79%, N 3.01%, O 17.17%, Cl 7.61%.
Properties
Crystals from ethyl methyl ketone, mp 105-107° (Ger. patent); also reported as mp 129-131° (Belg. patent).Therapeutic Category
Antispasmodic.
Keywords
Antispasmodic