5770. Mebhydroline

Nomenclature

CAS number: 524-81-2
2,3,4,5-Tetrahydro-2-methyl-5-(phenylmethyl)-1H-pyrido[4,3-b]indole; 5-benzyl-2,3,4,5-tetrahydro-2-methyl-1H-pyrido[4,3-b]indole; 3-methyl-9-benzyl-1,2,3,4-tetrahydro-γ-carboline; 5-benzyl-1,2,3,4-tetrahydro-2-methyl-γ-carboline; N-methyl-9-benzyltetrahydro-γ-carboline; Incidal.
C19H20N2; mol wt 276.38.
C 82.57%, H 7.29%, N 10.14%.

Description and references

Prepn: H"orlein, Ber. 87, 463 (1954); GB 721171 (1954 to Bayer); H"orlein, US 2786059 (1957 to Schenley). Pharmacology of Diazoline: Kharkevich, Farmakol. Toksikol. 20(no. 6), 46 (1957).

Chemical structure

Properties

Minute crystals, mp 95°. bp1 207-215°. Practically insol in water. Freely sol in methanol, ethanol, acetone, chloroform. Slightly sol in ether.

Derivative

1,5-Naphthalenedisulfonate salt.

Nomenclature

CAS number: 6153-33-9
Diazoline; Fabahistin (Bayer); Omeril (Bayer).
(C19H20N2)2.C10H8O6S2; mol wt 841.05.
C 68.55%, H 5.75%, N 6.66%, O 11.41%, S 7.62%.

Properties

White powder, dec 280°. Practically insol in water. Sparingly sol in hot glacial acetic acid. Sol in hot formamide, giving a yellow soln.

Therapeutic Category

Antihistaminic.

Keywords

Antihistaminic