5787. Medetomidine

Nomenclature

CAS number: 86347-14-0
5-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole; (±)-4-(α,2,3-trimethylbenzyl)imidazole; 4-[(α-methyl)-2,3-dimethylbenzyl]imidazole.
C13H16N2; mol wt 200.28.
C 77.96%, H 8.05%, N 13.99%.

Description and references

α2-Adrenergic agonist. Prepn: A. J. Karjalainen et al., GB 2101114; A. J. Karjalainen, K. O. A. Kurkela, US 4544664 (1983, 1985 both to Farmos). Receptor binding study: R. Virtanen et al., Eur. J. Pharmacol. 150, 9 (1988). LC/MS determn in plasma: H. Kanazawa et al., J. Chromatogr. 631, 215 (1993). Sedative and cardiovascular effects in humans: M. Scheinin et al., Br. J. Clin. Pharmacol. 24, 443 (1987). Veterinary evaluation in cats: D. Stenberg et al., J. Vet. Pharmacol. Ther. 10, 319 (1987); in horses and sheep: C. E. Bryant et al., Res. Vet. Sci. 65, 149 (1998); in elephants: B. Sarma et al., ibid. 73, 315 (2002). Review of pharmacology and use in dogs and cats: L. K. Cullen, Br. Vet. J. 152, 519-535 (1996).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 86347-15-1
MPV-785; Domitor (Orion); Sedator (Dechra).
C13H16N2.HCl; mol wt 236.74.
C 65.95%, H 7.24%, N 11.83%, Cl 14.98%.

Properties

White or almost white crystalline substance. Sol in water.

Derivative

d-Form see Dexmedetomidine.

Therapeutic Category (Veterinary)

Sedative; analgesic.