2946. Dexmedetomidine
Nomenclature
CAS number: 113775-47-6
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole; d-medetomidine; MPV-1440. C13H16N2; mol wt 200.28.
C 77.96%, H 8.05%, N 13.99%.
Description and references
α2-Adrenergic agonist; (+)-isomer of medetomidine, q.v. Prepn: A. J. Karjalainen et al., GB 2206880; eidem, US 4910214 (1989, 1990 both to Farmos). Physical properties: R. Rajala et al., Eur. J. Pharm. Sci. 1, 219 (1994). Clinical pharmacokinetics: P. Talke et al, Anesth. Analg. 85, 1136 (1997). Clinical evaluation as anesthetic adjunct: J. Jalonen et al., Anesthesiology 86, 331 (1997). Review of pharmacology and clinical experience for sedation of patients in intensive care: N. Bhana et al., Drugs 59, 263-270 (2000).
Derivative
Hydrochloride.Nomenclature
CAS number: 145108-58-3
Precedex (Abbott). C13H16CN2.HCl; mol wt 248.75.
C 67.60%, H 6.89%, N 11.26%, Cl 14.25%.
Properties
White or almost white crystalline powder, mp 156.5-157.5°. d 1.17 g/cm3. [α] +52.4° (c = 1 in water). pH of 1% soln in water: 4.3.Therapeutic Category
Sedative; analgesic.
Keywords
α-Adrenergic Agonist; Sedative/Hypnotic