5790. Medifoxamine

Nomenclature

CAS number: 32359-34-5
N,N-Dimethyl-2,2-diphenoxyethanamine; (dimethylamino)acetaldehyde diphenyl acetal; N,N′-dimethyl-2,2-diphenoxyethylamine.
C16H19NO2; mol wt 257.33.
C 74.68%, H 7.44%, N 5.44%, O 12.43%.

Description and references

Prepn: FR M5498 (1967 to Gerda), C.A. 72, 12358x (1970); M. A. Brunet et al., Bull. Soc. Chim. Fr. 6, 2000 (1967). Pharmacology and toxicity: A. Vagne et al., Therapie 26, 553 (1971). Clinical pharmacology: M. A. Randhawa et al., Hum. Psychopharmacol. 3, 195 (1988). Comparative clinical trial with clomipramine, q.v., in depression: H. Scharbach et al., Psychol. Med. 18, 1485 (1986).

Chemical structure

Derivative

Fumarate.

Nomenclature

CAS number: 16604-45-8
LG-152; Clédial (Anphar-Rolland); Gerdaxyl (Gerda).
C16H19NO2.C4H4O4; mol wt 373.40.
C 64.33%, H 6.21%, N 3.75%, O 25.71%.

Properties

Crystals from 95% ethanol, mp 128.5°. LD50 orally in rats: 750 mg/kg (Vagne).

Therapeutic Category

Antidepressant.

Keywords

Antidepressant