5791. Medrogestone

Nomenclature

CAS number: 977-79-7
6,17-Dimethylpregna-4,6-diene-3,20-dione; 6,17α-dimethyl-6-dehydroprogesterone; AY-62022; Colpro (Dagra); Colprone (Ayerst); Prothil (Kali-Chemie).
C23H32O2; mol wt 340.50.
C 81.13%, H 9.47%, O 9.40%.

Description and references

Prepn: Deghenghi, Gaudry, J. Am. Chem. Soc. 83, 4668 (1961); Deghenghi et al., Tetrahedron 19, 289 (1963); J. Med. Chem. 6, 301 (1963); Deghenghi, US 3133913, US 3210387; Morand, Deghenghi, US 3170936 (1964, 1965, and 1965, all to Am. Home Prod.). HPLC determn in serum: W. T. Robinson, L. Cosyns, Arzneim.-Forsch. 29, 882 (1979). Comparative clinical evaluation in benign prostatic hyperplasia: D. F. Paulson, R. D. Kane, J. Urol. 113, 811 (1975); in endometrial carcinoma: K. C. Podratz et al., Obstet. Gynecol. 66, 106 (1985).

Chemical structure

Properties

Crystals from ether, mp 144-146°. [α]D23 +79° (c = 1 in chloroform). uv max: 288 nm (ε 25000).

Therapeutic Category

Progestogen.

Keywords

Progestogen