5843. Meobentine

Nomenclature

CAS number: 46464-11-3
N-[(4-Methoxyphenyl)methyl]-N′,N″-dimethylguanidine; 1-(p-methoxybenzyl)-2,3-dimethylguanidine.
C11H17N3O; mol wt 207.27.
C 63.74%, H 8.27%, N 20.27%, O 7.72%.

Description and references

Antidysrhythmic, antifibrillatory deriv of guanidine, q.v. Prepn of the sulfate: R. A. Maxwell, E. Walton, DE 2030693 corresp to US 3949089 (1971, 1976 both to Burroughs Wellcome). Antidysrhythmic effects and tissue concentration: K. B. Touw et al., Pharmacologist 19, 268 (1977); K. B. Touw, Diss. Abstr. B 39, 5340 (1979). Pharmacokinetics by radioimmunoassay: J. W. A. Findlay et al., Pharmacologist 21, 337 (1979). Pharmacological study: W. B. Wastila et al., J. Pharm. Pharmacol. 33, 594 (1981).

Chemical structure

Derivative

Sulfate.

Nomenclature

CAS number: 58503-79-0
Rythmatine (Burroughs Wellcome).
(C11H17N3O)2.H2SO4; mol wt 512.62.
C 51.55%, H 7.08%, N 16.39%, O 18.73%, S 6.26%.

Properties

Cryst, mp 273-274°.

Therapeutic Category

Antiarrhythmic (class III).

Keywords

Antiarrhythmic