5851. Mephenoxalone

Nomenclature

CAS number: 70-07-5
5-[(2-Methoxyphenoxy)methyl]-2-oxazolidinone; 5-(o-methoxyphenoxymethyl)-2-oxazolidinone; metoxadone; methoxydon(e); methoxadone; AHR-233; OM-518; Dorsiflex (Drossapharm); Control-Om (OM); Xerene (Martinet).
C11H13NO4; mol wt 223.23.
C 59.18%, H 5.87%, N 6.27%, O 28.67%.

Description and references

Prepn: Lunsford et al., J. Am. Chem. Soc. 82, 1166 (1960); Lunsford, US 2895960 (1959 to A. H. Robins). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971). Determn in pharmaceutical formulations: N. Erk, J. Pharm. Biomed. Anal. 21, 429 (1999).

Chemical structure

Properties

Crystals from 95% ethanol, mp 143-145°. Water insol. LD50 orally in rats: 3820 ±17 mg/kg (Goldenthal).

Therapeutic Category

Muscle relaxant (skeletal).

Keywords

Muscle Relaxant (Skeletal)