5853. Mephenytoin

Nomenclature

CAS number: 50-12-4
5-Ethyl-3-methyl-5-phenyl-2,4-imidazolidinedione; 5-ethyl-3-methyl-5-phenylhydantoin; 3-methyl-5,5-phenylethylhydantoin; “methyl hydantoin”; phenylethylmethylhydantoin; 3-ethylnirvanol; methoin; Insulton; Mesontoin; Mesantoin (Sandoz); Phenantoin; Sedantoinal (Sandoz); Gerot-Epilan (Gerot); Sacerno (EGYT).
C12H14N2O2; mol wt 218.25.
C 66.04%, H 6.47%, N 12.84%, O 14.66%.

Description and references

Prepn: FR 769667; CH 166004 (both 1934 to Sandoz); CH 179692 (1935 to Sandoz). Pharmacology: I. A. Dzhagatspanyan et al., Pharm. Chem. J. 25, 181 (1991).

Chemical structure

Properties

Crystals, mp 136-137°. Insol in water. Forms a water-soluble sodium salt which has an alkaline reaction. LD50 i.p. in mice: 300 mg/kg (Dzhagatspanyan).

Therapeutic Category

Anticonvulsant.

Keywords

Anticonvulsant