5861. Meprednisone
Nomenclature
CAS number: 1247-42-3
(16β)-17,21-Dihydroxy-16-methylpregna-1,4-diene-3,11,20-trione; 16β-methylprednisone; Betapred (Schering); Betapar (Parke-Davis); Betalone (Lepetit); Deltisona B. C22H28O5; mol wt 372.45.
C 70.95%, H 7.58%, O 21.48%.
Description and references
Prepn: E. P. Oliveto et al., J. Am. Chem. Soc. 80, 4428 (1958); D. Taub et al., ibid. 4435; D. Taub et al., ibid. 82, 4012 (1960); G. G. Nathansohn et al., Experientia 17, 448 (1961); GB 901092 (1962 to Scherico); R. Rausser, E. P. Oliveto, US 3164618 (1965 to Schering).
Properties
Crystals, mp 200-205°. [α]D +200° (dioxane). uv max (methanol): 239 nm (E1%1cm 416).Derivative
21-Acetate.C24H30O6; mol wt 414.49.
C 69.54%, H 7.30%, O 23.16%.
Properties
mp 232-235°. [α]D +210° (dioxane). uv max (methanol): 238 nm (E1%1cm 358).Therapeutic Category
Glucocorticoid.
Keywords
Glucocorticoid