5920. Metaclazepam

Nomenclature

CAS number: 84031-17-4
7-Bromo-5-(2-chlorophenyl)-2,3-dihydro-2-(methoxymethyl)-1-methyl-1H-1,4-benzodiazepine; brometazepam; metuclazepam; Ka-2547; KC-2547.
C18H18BrClN2O; mol wt 393.71.
C 54.91%, H 4.61%, Br 20.30%, Cl 9.00%, N 7.12%, O 4.06%.

Description and references

Benzodiazepine deriv with alkoxymethyl group replacing carbonyl in parent compd. Prepn: W. Milkowski et al., DE 2221558; eidem, US 4098786 (1973, 1978 both to Kali-Chemie). Effect on psychomotor performance and memory in volunteers: Z. Subhan, I. Hindmarch, Drugs Exp. Clin. Res. 9, 567 (1983). Interaction with ethanol: H. R. Musch, M. Ruhland, Arzneim.-Forsch. 32, 567 (1982); H. J. Mallach et al., Blutalkohol 20, 196 (1983); V. Schmidt et al., Med. Welt 35, 32 (1984). Clinical studies: G. Laakman et al., Arzneim.-Forsch. 30, 1233 (1980).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 61802-93-5
Talis (Kali-Chemie).
C18H18BrClN2O.HCl; mol wt 430.17.
C 50.26%, H 4.45%, Br 18.57%, Cl 16.48%, N 6.51%, O 3.72%.

Properties

Crystals from ethanol, mp 193-196°. LD50 orally in NMRI white mice: 1578 mg/kg (Milkowski).

Therapeutic Category

Anxiolytic.

Keywords

Anxiolytic; Benzodiazepine Derivatives