5964. Methdilazine

Nomenclature

CAS number: 1982-37-2
10-[(1-Methyl-3-pyrrolidinyl)methyl]-10H-phenothiazine.
C18H20N2S; mol wt 296.43.
C 72.93%, H 6.80%, N 9.45%, S 10.82%.

Description and references

Prepn: Feldkamp, Wu, US 2945855 (1960 to Mead Johnson). Toxicity data: E. I. Goldenthal, Toxicol. Appl. Pharmacol. 18, 185 (1971).

Chemical structure

Properties

Crystals, mp 87-88°.

Derivative

Hydrochloride.

Nomenclature

CAS number: 1229-35-2
Dilosyn; Disyncran; Tacaryl (Westwood).
C18H20N2S.HCl; mol wt 332.89.
C 64.94%, H 6.36%, N 8.42%, S 9.63%, Cl 10.65%.

Properties

Crystals from isopropyl alc, mp 187.5-189°. LD50 orally in rats: 320 mg/kg (Goldenthal).

Therapeutic Category

Antipruritic.

Keywords

Antipruritic