5968. Methestrol

Nomenclature

CAS number: 130-73-4
4,4′-(1,2-Diethyl-1,2-ethanediyl)bis[2-methylphenol]; 4,4′-(1,2-diethylethylene)di-o-cresol; 3,4-bis(3-methyl-4-hydroxyphenyl)hexane; dimethylhexestrol; promethestrol; γ-promethestrol.
C20H26O2; mol wt 298.42.
C 80.50%, H 8.78%, O 10.72%.

Description and references

Prepd by hydrolysis of the dipropionate: Niederl et al., J. Am. Chem. Soc. 70, 508 (1948). Chromatographic identification and determn: R. W. Roos, J. Pharm. Sci. 63, 594 (1974). Pharmacologic study: P. H. Jellinck, A. M. Newcombe, Biochem. Pharmacol. 29, 3031 (1980). Pharmacotherapeutic study: C. B. Hammond, W. S. Maxson, Fertil. Steril. 37, 5 (1982).

Chemical structure

Properties

Crystals from dil acetic acid, mp 145°.

Derivative

Dipropionate.

Nomenclature

Meprane Dipropionate (Reed & Carnrick).
C26H34O4; mol wt 410.55.
C 76.06%, H 8.35%, O 15.59%.

Properties

Cryst, mp 115°. Freely sol in ether, ethyl acetate, benzene; slightly sol in alc. Practically insol in water, dil acids.

Therapeutic Category

Estrogen.

Keywords

Estrogen; Nonsteroidal