5994. Methoxyflurane

Nomenclature

CAS number: 76-38-0
2,2-Dichloro-1,1-difluoro-1-methoxyethane; 2,2-dichloro-1,1-difluoroethyl methyl ether; 1,1-difluoro-2,2-dichloroethyl methyl ether; DA-759; Metofane (Vericore); Penthrane (Abbott); Pentrane (Abbott).
C3H4Cl2F2O; mol wt 164.97.
C 21.84%, H 2.44%, Cl 42.98%, F 23.03%, O 9.70%.

Description and references

Prepn and properties: Miller et al., J. Am. Chem. Soc. 70, 431 (1948); Park et al., ibid. 73, 861 (1951); GB 754976 (1956 to Standard Tele. & Cable).

Chemical structure

Properties

Liquid, bp 105°; bp100 51°. mp 35°. nD20 1.3861; nD25 1.3839. d420 1.4262 (Miller); d420 1.4226 (Park).

Caution

Potential symptoms of overexposure are eye irritation; CNS depression, analgesia; anesthesia, seizures, respiratory depression; liver and kidney injury. See NIOSH Pocket Guide to Chemical Hazards (DHHS/NIOSH 97-140, 1997) p 196.

Therapeutic Category

Anesthetic (inhalation).

Therapeutic Category (Veterinary)

Anesthetic.

Keywords

Anesthetic (Inhalation)