6003. Methscopolamine Bromide

Nomenclature

CAS number: 155-41-9
(1α,2β,4β,5α,7β)-7-[(2S)-3-Hydroxy-1-oxo-2-phenylpropoxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide; 6β,7β-epoxy-3α-hydroxy-8-methyl-1αH,5αH-tropanium bromide tropate (ester); N-methylscopolammonium bromide; hyoscine methyl bromide; scopolamine methobromide; scopolamine methyl bromide; epoxymethamine bromide; Holopon (Altana); Pamine (Bradley).
C18H24BrNO4; mol wt 398.29.
C 54.28%, H 6.07%, Br 20.06%, N 3.52%, O 16.07%.

Description and references

Anticholinergic. Prepd by the action of methyl bromide on scopolamine base: Visscher, US 2753288 (1956 to Upjohn). Treatment of duodenal ulcer by transdermally administered methscopolamine bromide: R. P. Walt et al., Br. Med. J. 284, 1736 (1982).

Chemical structure

Properties

Crystals from ethanol, dec 214-217°. Freely sol in water, in dil ethanol. Slightly sol in abs ethanol.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic; Antimuscarinic