6004. Methsuximide

Nomenclature

CAS number: 77-41-8
1,3-Dimethyl-3-phenyl-2,5-pyrrolidinedione; N,2-dimethyl-2-phenylsuccinimide; 1,3-dimethyl-3-phenyl-2,5-dioxopyrrolidine; mesuximide; Celontin (Parke-Davis); Petinutin (Parke-Davis).
C12H13NO2; mol wt 203.24.
C 70.92%, H 6.45%, N 6.89%, O 15.74%.

Description and references

Prepd by the action of methylamine on α-methyl-α-phenylsuccinic acid: Miller, Long, J. Am. Chem. Soc. 73, 4895 (1951); eidem, US 2643257 (1953 to Parke, Davis). Pharmacology: P. G. Marshall, D. K. Vallance, J. Pharm. Pharmacol. 6, 740 (1954).

Chemical structure

Properties

Crystals from dil alc, mp 52-53°. bp0.1 121-122°. Freely sol in methanol, alc. LD50 orally in mice: 0.9 g/kg (Marshall, Vallance).

Therapeutic Category

Anticonvulsant.

Keywords

Anticonvulsant