6023. Methylbenzethonium Chloride
Nomenclature
CAS number: 25155-18-4
N,N-Dimethyl-N-[2-[2-[methyl-4-(1,1,3,3-tetramethylbutyl)phenoxy]ethoxy]ethyl]benzenemethanaminium
chloride; benzyldimethyl[2-[2-(p-1,1,3,3-tetramethylbutylcresoxy)ethoxy]ethyl]ammonium
chloride; [2-[2-(p-octylcresoxy)ethoxy]ethyl]dimethylbenzylammonium
chloride; benzyldimethyl[2-[2-[4-(1,1,3,3-tetramethylbutyl)tolyloxy]ethoxy]ethyl]ammonium
chloride. C28H44ClNO2; mol wt 462.11.
C 72.77%, H 9.60%, Cl 7.67%, N 3.03%, O 6.92%.
Description and references
Quaternary ammonium salt with antimicrobial activity. Germicidal activity: F. Hart, C. L. Huyck, J. Am. Pharm. Assoc. Sci. Ed. 37, 272 (1948). In vitro activity vs Leishmania major: J. El-On, G. Messer, Am. J. Trop. Med. Hyg. 35, 1110 (1986). Clinical trial in combination with paramomycin, q.v., in cutaneous leishmaniasis: G. Krause, A. Kroeger, Trans. R. Soc. Trop. Med. Hyg. 88, 92 (1994). Review of properties, commercial uses and toxicology: J. Am. Coll. Toxicol. 4, 65-106 (1985).
Derivative
Monohydrate.Nomenclature
CAS number: 1320-44-1
Diaparene (Sterling Winthrop); Hyamine 10X (Rohm & Haas). Properties
Bitter tasting crystals, mp 161-163°. Freely sol in water, alcohol, cellosolve, chloroform, hot benzene. LD50 in rats (mg/kg): 100 s.c. (Hart, Huyck).Use
In cosmetics as preservative; cationic surfactant.Therapeutic Category
Antiseptic, disinfectant.
Keywords
Antiseptic/Disinfectant; Quaternary Ammonium Compounds